Chondrocyte ferroptosis
Web3.2 AMPK/SIRT3 pathway. Similar to SIRT1, silent information regulator 3 (SIRT3) is an NAD + -dependent protein deacetylase that is activated when translocated to mitochondria (Ansari et al., 2024).SIRT3 is an important regulator of chondrocyte energy metabolism, and SIRT3 enhances the antioxidant activity of superoxide dismutase (SOD2) to protect … WebFerroptosis is a novel form of cell death that differs from apoptosis and autophagy, recent studies have shown that chondrocyte ferroptosis contributes to the development of osteoarthritis.
Chondrocyte ferroptosis
Did you know?
WebMar 1, 2024 · Erastin-induced chondrocyte ferroptosis can stimulate increased MMP13 expression and decreased collagen II expression in chondrocytes. DFO can suppress chondrocyte ferroptosis and promote... WebSep 19, 2024 · Ferroptosis is an iron-dependent regulated cell death that requires the accumulation of iron and lipid peroxides, both of which impair cartilage …
WebApr 12, 2024 · In addition, the ferroptosis‑specific inhibitor ferrostatin‑1 (Fer‑1) and the autophagy inhibitor 3‑methyladenine abolished ACR‑induced cell death in chondrocytes. ACR was shown to activate autophagic flux and induce mitochondrial dysfunction by increasing the MMP. Western blot analysis of ferroptosis‑related proteins demonstrated ... WebFerroptosis-related alterations were analyzed in human OA and undamaged cartilage. Expression of GPX4 was examined in 55 paired human OA samples. Ferrostatin-1 (Fer-1) and Deferoxamine (DFO) were used to treat OA, in vitro and in vivo. Alterations of GPX4-mediated signaling pathway were identified by RNA-seq analysis.
WebOct 4, 2024 · Ferroptosis is a new therapeutic target for the intervention of IVDD. The role of ferroptosis in the modulation of intervertebral disc degeneration (IVDD) is a significant topic of interest. This is a novel research topic, and research on the mechanisms of IVDD and ferroptosis is ongoing. WebMar 14, 2024 · Erastin-induced chondrocyte ferroptosis can stimulate increased MMP13 expression and decreased collagen II expression in chondrocytes. DFO can suppress …
WebSep 25, 2024 · Recent evidence has indicated that chondrocyte ferroptosis contributes to the progression of OA. 9 Iron‐overloaded mice exhibit increased cartilage destruction, …
WebMar 10, 2024 · Chondrocytes are the main cell damage type involved in the occurrence and development of osteoarthritis (OA). Ferroptosis has been confirmed to be related to many degenerative diseases. This research aimed to explore the role of Sp1 and ACSL4 in ferroptosis in the IL-1β-treated human chondrocyte cells line (HCCs). Methods one cup of blueberries nutritionWebThis suggests that the genetic or pharmacological inhibition of TRPM7 could alleviate RA cartilage destruction by reducing chondrocyte ferroptosis [83]. In conclusion, TRPM7 is an effective ... is bali near australiaWebApr 12, 2024 · These results suggested that chondrocytes ferroptosis play an important role in the development and progression of TMJOA. Inhibition of condylar chondrocyte … is bali in the south pacificWebJun 28, 2024 · Chondrocyte ferroptosis is closely associated with the development of OA. As a common drug administered for the treatment of type 2 diabetes, metformin (Met) is known to inhibit the development of ferroptosis. However, its therapeutic effect in OA remains unknown. is bali in the usWebMar 6, 2024 · Human chondrocytes were applied to validate the above findings in the scenario of ferroptosis inhibitors administration. Results partially proved the consistency with bioinformatics analyses that ATF3 and TFRC were highly expressed in interleukin-1β (IL-1β)-stimulated chondrocytes whereas CXCL2 and JUN were downregulated. is bali in thailandWebApr 12, 2024 · In addition, the ferroptosis‑specific inhibitor ferrostatin‑1 (Fer‑1) and the autophagy inhibitor 3‑methyladenine abolished ACR‑induced cell death in chondrocytes. … one cup of butter equals how many sticksWebLiproxstatin-1 alleviates cartilage degradation by inhibiting chondrocyte ferroptosis in temporomandibular joint. biorxiv.org. comments sorted by Best Top New Controversial Q&A Add a Comment sorted by Best Top New Controversial Q&A Add a Comment one cup of cheese