WebAug 1, 2013 · UV-induced formation of the thymine-thymine pyrimidine (6-4) pyrimidone photoproduct — a DFT study of the oxetane intermediate ring opening Vanessa Labet, Nelly Jorge, Christophe Morell, Thierry Douki, André Grand, Jean Cadet & Leif A. Eriksson Photochemical & Photobiological Sciences 12 , 1509–1516 ( 2013) Cite this article 17 …
Antigen structural requirements for recognition by a cyclobutane ...
WebOct 15, 2003 · The cyclobutane thymine dimer is the major DNA lesion induced in human skin by sunlight and is a primary cause of skin cancer, the most prevalent form of cancer in the Northern Hemisphere. In humans, the only known cellular repair mechanism for eliminating the dimer from DNA is nucleotide excision repair. Yet the mechanism by … A cyclobutane pyrimidine dimer (CPD) contains a four membered ring arising from the coupling of the two double-bonded carbons of each of the pyrimidines. Such dimers interfere with base pairing during DNA replication, leading to mutations. A 6–4 photoproduct (6–4 pyrimidine–pyrimidone or 6–4 … See more Pyrimidine dimers are molecular lesions formed from thymine or cytosine bases in DNA via photochemical reactions, commonly associated with direct DNA damage. Ultraviolet light (UV; particularly UVB) … See more Due to the excellent photochemical properties of DNA, this nature-made molecule is damaged by only a tiny fraction of the … See more Pyrimidine dimers introduce local conformational changes in the DNA structure, which allow recognition of the lesion by repair enzymes. In most organisms (excluding placental mammals such as humans) they can be repaired by photoreactivation. … See more • DNA repair See more Translesion polymerases frequently introduce mutations at pyrimidine dimers, both in prokaryotes (SOS mutagenesis) and in eukaryotes. … See more A study by Hanson suggests sunscreen that penetrates into the skin and thereby amplifies the amount of free radicals and oxidative stress contributes to the formation of melanoma, but this idea has not been validated by other researchers. See more Direct DNA damage is reduced by sunscreen. This prevents sunburn. When the sunscreen is at the surface of the skin, it filters the UV rays, which attenuates the intensity. Even … See more prof rainer mausfeld
Recognition and repair of the cyclobutane thymine dimer, …
WebInstead, repair of classical NER substrates, cyclobutane pyrimidine dimer and N-(deoxyguanosin-8-yl)-2-acetylaminofluorene, occurred even when TC-NER was disrupted. The strict requirement of TC-NER highlights cyclo-dA and cyclo-dG as candidate damage types, accountable for cytotoxic and degenerative responses in individuals affected by … WebThe study addresses interconnected issues related to two major types of cycloadditions between adjacent thymines in DNA leading to cyclobutane dimers (T<>Ts) and (6-4) adducts. Experimental results are obtained for the single strand (dT)(20) by steady-state and time-resolved optical spectroscopy, as well as by HPLC coupled to mass spectrometry. WebRing opening of the cyclobutane in a thymine dimer radical anion. The reactions of hydrated electrons (e(aq) (-)) with thymine dimer 2 and thymidine have been … kvw arche