Web18 aug. 1998 · These data suggest that IRF-3 has an important role in virus-mediated induction of both IFNA and IFNB genes. While this paper was being completed, Yoneyama et al. ( 19) showed that IRF-3 increases virus-mediated induction of IFNA and IFNB genes in L cells. IFN Signaling Pathway Is Critical for IRF-3-Mediated Antiviral Effect. Web13 apr. 2024 · P2rx1 knockout (KO) mice (P2rx1−/−) with 300 mg/kg APAP challenge were used for the analysis of the potential role of P2RX1 in the progression of AILI. Administration of DMX, the activator of stimulator of interferon genes (STING), was performed to investigate the effects of the STING-related pathway on APAP-treated P2rx1−/− mice.
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WebDichloroacetate modulates cytokines toward T helper 1 function via induction of the interleukin-12–interferon-γ pathway Mujtaba M Badr,1,2 Nidal A Qinna,1,2 Fadi Qadan,2 Khalid Z Matalka1,2 1Department of Pharmacology and Biomedical Sciences, Faculty of … Web3 mrt. 2024 · IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formation Semantic Scholar DOI: 10.1080/2162402X.2024.2044103 Corpus ID: 247275757 IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA … clackety keyboard
Type I interferon–mediated autoimmune diseases ... - Oxford …
Web29 mrt. 2024 · Whilst principally known for its role in proinflammatory gene induction, IRF8 also reportedly takes part in a second phase of interferon induction in dendritic cells in … WebInduction of interferon (IFN) gene expression leads to increase cellular resistance to viral infection and may also affect cell growth. Two subtypes of interferons comprise the … Web5 feb. 2008 · Thus, it would be intriguing to investigate whether IFN-induction mechanisms not relying on IRF3 may exist in cells other than plasmacytoid DC. Different cells may … clackety track