Web9 dec. 2024 · Based on the present findings, we suggest that ion-pair receptors 1–3 could emerge as chemical tools that are useful in modulating intracellular cation concentrations … Web9 dec. 2024 · Multiple previous studies have shown that disruption of potassium ion homeostasis in cells is closely related to the onset of apoptosis. 11 Agents that disrupt cellular potassium ion homeostasis can, thus, induce apoptosis. 2 For instance, valinomycin, a naturally occurring K +-selective ionophore that enhances K + efflux, was …
Ion channel hypothesis of Alzheimer
WebDamage to mitochondria affects the intracellular energy metabolic homeostasis, thereby aberrantly regulating autophagy and increasing apoptosis and fibrotic degeneration of cardiomyocytes [14]. Therefore, we hypothesized that the induction of cardiomyocyte apoptosis by DOX through the inhibition of autophagy is an essential element in the … Web12 apr. 2024 · Background: Organophosphate esters (OPEs) are common endocrine-disrupting chemicals, and OPE exposure may be associated with type 2 diabetes (T2D). However, greater knowledge regarding the biomolecular intermediators underlying the impact of OPEs on T2D in humans are needed to understand biological etiology. … porshe industrial designer
Potential Roles of Electrogenic Ion Transport and Plasma …
WebApoptosis is a very important factor in an organism’s development, especially at the embryonic stage and in normal renewing tissue homeostasis (for example in epithelial … Web17 jun. 2024 · Ion fluxes across the inner mitochondrial membrane control mitochondrial volume, energy production, and apoptosis. TMBIM5, a highly conserved protein with homology to putative pH-dependent ion channels, is involved in the maintenance of mitochondrial cristae architecture, ATP production, and apoptosis. Here, we … Web14 sep. 2024 · Park et al. report three artificial ion-pair receptors that act as efficient Na+/K+ exchangers in the presence of Cl−, not only in liposomal models but also in vitro. They promote Na+/K+ exchange in cancer cells, thereby inducing apoptosis. Mechanistic studies reveal that these cation exchangers induce endoplasmic reticulum (ER) stress in cancer … irish inn shamrock texas