Plk2 function
WebbPlk2 is a target of p53. Our previous studies demonstrated that with wild-type p53, Plk2 impacts mTOR signaling in the same manner as TSC1, and Plk2-deficient tumors grew larger than control. Other investigators have demonstrated that Plk2 phosphorylates … WebbWorld renowned, passionate experienced cell signalling biologist. Several breakthrough discoveries changing the understanding of signalling and a track record of more than 60 publications. More than 17Y experience in pharmaceutical industry . Identification and validation of drug discovery targets and target and disease relevant assay development …
Plk2 function
Did you know?
Webb13 apr. 2024 · Functional enrichment analysis of top 25 hubs in RR-MS and GSE101878 ZIKV PPIs by ... and the RR-MS lists of DEGs, we observed that JUN, FOS, PLK2, DDIT4, CRELD2, and TIPARP are commonly upregulated in all three signatures. Interestingly, these genes encompass the enrichment of relevant biological themes, such as response to ... WebbThe POLO box domains act as phosphopeptide-binding module that recognize and bind serine- [phosphothreonine/phosphoserine]- (proline/X) motifs. PLK2 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then …
WebbPurpose: To identify radiation-induced early transcriptional responses in primary human fibroblasts and understand cellular pathways leading to damage correction. Methods and Materials: Primary human fibroblast cell lines were irradiated with 2 Gy γ-radiation and RNA isolated 2 h later. Radiation-induced transcriptional alterations were investigated with … Webb7 feb. 2011 · The polo-like kinase-2, Plk2, is activated near the G(1)/S phase transition, and plays an important role in the reproduction of centrosomes. In this study, we show that the polo-box of Plk2 is required both for association to the centrosome and centriole …
Webb•PlK2 functions downstream of Npas4 to modulate MF-CA3 synapses Summary ... These findings demonstrate that rhIGF1 corrects functional, structural, ... http://www.cancerindex.org/geneweb/PLK2.htm
WebbAn intersting research on peptide properties prediction using deep learning models! Researchers here present three different models for hemolysis…
Webb8 juni 2010 · On the basis of the results, we propose a model in which PLK2 phosphorylation is critical for CPAP function in procentriole assembly during the cell cycle . CPAP may be recruited to the centrosome as it is synthesized; however, to participate in … hatchers on target bbq alcoaWebb26 maj 2015 · Using a combination of high-resolution in vivo imaging of zebrafish vascular development and a human umbilical vein endothelial cell (HUVEC) in vitro cell culture system, we observed that loss of PLK2 function resulted in a reduction in endothelial cell … hatchers onlineWebb25 juni 2008 · Thus, Plk2 function is required to prevent escalating potentiation and maintain synapses in a plastic state during epileptiform activity in hippocampal slice cultures. How homeostatic plasticity is achieved at the molecular level during … booth brothers songs freeWebbHere we used molecular simulation to provide insight in the selective phosphorylation by polo-like kinase 2 (PLK2), in both monomeric and fibrillar forms of AS. We suggest that phosphorylation does not impact on the structural determinants of the physiological AS conformational ensemble, as the phosphate group is mostly solvated. hatcher southwestWebbThe polo-box domain (PBD) of Plk1 is a promising target for cancer therapeutics. We designed and synthesized novel phosphorylated macrocyclic peptidomimetics targeting PBD based on acyclic... hatchers pass 2020 freeWebbPLK2 is essential for mitotic centriole replication and meiotic chromatin pairing, synapsis, and crossing-over in the cell cycle; Loss of PLK2 function results in cell cycle disorders and ... booth brothers through it all youtubeWebbHere we investigated the effects of this novel mutation on the biophysical properties of α-Syn and the consequences for its cellular function. We found that the H50Q mutation affected neither the structure of free or membrane-bound α-Syn monomer nor its interaction with metals or its capacity to be phosphorylated in vitro. booth brothers speak jesus